| 1888 | Los Angeles Chamber of Commerce founded | |
| Chamber holds first meeting at livery stable at First and Broadway | ||
| 1889 | After just five months, the Chamber relocates to its second office at the Northeast corner of First Street | |
| 1890 | Frank Wiggins, pioneer of Los Angeles developments, joins Chamber staff as Superintendent of Exhibits | |
| The federal government explores development of deep water port in Los Angeles after Chamber presents a resolution to Congress | ||
| Chamber relocates for a third time to office space on Main Street between First and Second | ||
| 1891 | Chamber sends a liberty bell of oranges to the Citrus Carnival | |
| 1893 | Chamber aides the creation of Southern California Fruit Growers and its nonprofit organization Sunkist | |
| Wiggins orders construction of famous walnut elephant for the Chicago World's Fair | ||
| 1894 | Chamber relocates to its fourth location at Fourth and Broadway | |
| 1895 | Free Harbor League forms to lobby for San Pedro site | |
| 1896 | Conventions department of the Chamber secures National Education Association Convention, representing the first national convention held in Los Angeles | |
| 1904 | Chamber relocates to its fifth location at 130 S. Broadway | |
| 1910 | Chamber organizes the first international Dominguez Air Meet at Dominguez Field | |
| 1913 | San Fernando Valley Aqueduct opens after extensive lobby made by the Chamber | |
| 1918 | Chamber hires photographer Eyre Powell to help transform Los Angeles into a household name in America | |
| Dr. Ford Carpenter joins Chamber staff as manager of the new Department of Meteorology and Aeronautics | ||
| 1921 | Chicago livestock entrepreneurs receive Chamber support in developing the Central Manufacturing District and the Los Angeles Junction Railway | |
| 1925 | Chamber relocates for the sixth time to 1151 Twelfth Street | |
| Junior Chamber of Commerce organizes to promote trade and extend manufacturing within the state | ||
| 1927 | Stanley T. Olafson, Chamber staff member, initiates World Trade Week to increase community knowledge about the value of foreign trade | |
| Municipal airport actively supported by the Chamber | ||
| 1931 | Photographer Newton Berlin joins Chamber staff to document factories, large industries and small businesses | |
| 1932 | Los Angeles hosts the Olympic Games | |
| Women's division organizes to assist with Olympic visitors and forms the Southern California Festival of Allied Arts | ||
| 1938 | Chamber officials mobilize Los Angeles community to support federal wartime preparedness | |
| 1942 | The Chamber's Free Enterprise Committee becomes Free Enterprise Forum to help spotlight cases of federal interference in business and dangerous governmental practices | |
| 1946 | Chamber successfully fights for legislation to finance construction of freeways in Los Angeles | |
| 1956 | Chamber relocates for the seventh time to 404 S. Bixel | |
| Air Pollution Control District and Chamber create "Share the Ride" campaign | ||
| 1958 | Chamber attracts Dodgers to Los Angeles | |
| 1967 | Chamber changes name to Los Angeles Area Chamber of Commerce | |
| 1971 | Los Angeles Convention Center opens through Chamber efforts | |
| 1973 | First Break Program for Los Angeles Unified School District (LAUSD) students begins its inaugural year representing a partnership between the Chamber and LAUSD to place thousands of students in their first jobs | |
| 1984 | Olympics return to Los Angeles through support of Chamber | |
| 1985 | Chamber testifies before Congress on behalf of Metro Rail System | |
| 1993 | Chamber's advocacy efforts result in passage of NAFTA | |
| 1994 | Chamber coordinates with Red Cross, FEMA and other governmental agencies to provide earthquake victims relief | |
| Chamber relocates for the eighth time to 350 S. Bixel St. | ||
| 1998 | Alameda Corridor construction begins after a decade of advocacy from the Chamber | |
| 2002 | Chamber and L.A. County Metropolitan Transportation Agency create Mobility 21 to lobby for transportation solutions and funding | |
| Chamber leads successful effort to defeat the secession of San Fernando Valley, San Pedro and Hollywood from the City of Los Angeles | ||
| 2003 | Chamber acquires LA Youth at Work and partners with UNITE-LA to form new Education & Workforce Development division | |
| Elected officials participate in new Chamber program called Pancakes & Politics Breakfast Speaker Series | ||
| 2005 | Chamber creates partnership with Southern California Leadership Network, which includes core programs Leadership Los Angeles and Leadership Southern California | |
| 2006 | Chamber co-sponsors term limit reform for the L.A. City Council | |
| Chamber and other business organizations support $40 billion in infrastructure improvements for California | ||
| 2008 | Chamber supports the fifth school bond issue to relieve overcrowding in LAUSD | |
| Chamber co-sponsors Proposition 11 which creates a citizens commission to draw new legislative districts after each census | ||
| Chamber successfully supports Measure R, a half-cent sales tax for Los Angeles County that would finance new transportation projects and programs | ||
| 2009 | Chamber lobbies the Mayor and L.A. City Council to create an Office of Economic Analysis | |
| Chamber sponsors first Americas' Business Forum for the Americas with UCLA and the U.S. Foreign and Commercial Service | ||